24 May 2008

Shopping

Have you heard about Black Friday? Well now, I will tell you about it. Black Friday is the day after Thanksgiving when major retailers everywhere discount products to help launch the Christmas shopping season. These great Black Friday ads are normally kept secret until you receive the circulars in your Thanksgiving Day newspaper. But at Black-Friday.net, they hand you the advantage of showing you all of the Black Friday 2008 ads before anyone else. Using something like this Black Friday website can save you big time on many fabulous products but not only that there are other benefits as well. For instance, you will not have to get up at the crack of dawn to go and stand in line at one of the department stores just for the privilege of perhaps laying your hands on that last minute gift for you loved ones. Check out the 2008 thanksgiving specials for some great bargains.

This site is very useful in that it can really take the stress out of your last minute holiday shopping. It was a success last year and I am sure that it will be again this year. The holidays can be fraught and manic enough without the stress and anxiety of having to brace the shopping hordes in shopping malls and large department stores. Anything that can help with this is a good thing and Black-Friday.net can certainly help you with this so do check it out if you are interested in a more streamlined holiday shopping experience. I would wholeheartedly recommend it.

Brought to you by Black Friday

Sydney Writers Festival

A friend of mine, a writer from Sydney, will soon be speaking at the annual Sydney Writers Festival. She has recently had a great book deal and is now getting invited to speak at festivals and cultural events around Australia. I am very pleased for her as she is a lovely person who deserves this success in her chosen field. I only wish I could be there to hear her speak.

22 May 2008

Violins have more than one string

Science is one of those endlessly fascinating games that people play with ideas. The method could not be easier to state. You propose a hypothesis and design an experiment to collect evidence to test whether your hypothesis is true (I always pay particular attention when anyone starts talking about truth — if ever there was a flexible friend, truth would be it). So, now your results are in. You claim definitive evidence that “proves” what you speculated was either true or not true. Now it is up to the rest of the world to see whether it can replicate your findings. The more independent people who can reproduce the same results, the more likely it is that your hypothesis is true or not true.

As an irrelevant aside given that I am writing about acomplia, did you see that they are cooling down the Large Hadron Collider (LHC), near Geneva, to look more closely for Higgs boson — the controvesially-named “God” particle. And, hoping that you will forgive me for a flippant moment, weight loss is also increasingly a “holy grail” given the epidemic proportions of the spread of obesity in the human population. So, this April has seen the results of the Stradivarius study published in the Journal of the American Medical Association, and featured in a presentation and discussion at the Annual Scientific Meeting of the American College of Cardiology held at Chicago.

The Strategy to Reduce Atherosclerosis Development Involving Administration of Rimonabant - The Intravascular Ultrasound Study (that is Stradivarius for short) has been looking for evidence that acomplia (generic name riminobant) will slow down the progression of heart disease among overweight individuals whose arteries are hardening. In other words, the trial was trying to define a specific role for acomplia in the treatment of cardiovascular disease. Now a simple headline statement of the results — much to the disappointment of the College of Cardiology, there was no evidence that acomplia had any effect in slowing down the progression of atherosclerosis. You cannot imagine an audience more likely to be disappointed and therefore downbeat about acomplia. But, like those canny Scottish lawyers, I have a third wheel to my justice system. You are guilty, not guilty or the case is “not proven”. So the specific hypothesis of the Stradivarius trial is not proven. We still do not know to what extent acomplia may or may not have a part to play in the treatment of cardiovascular disease. But the other parts of acomplia continued to play in Stradivarius according to specification.

Stradivarius had 839 participants with an average BMI 35, whose average waist measurements were 46 inches. After eighteen months, those taking acomplia had lost an average 9.5 pounds and had trimmed their waist measurements by an average of 1.8 inches. Those taking acomplia showed improvement in other factors affecting the risk of cardiovascular disease: high-density cholesterol had risen by 22.4%, triglycerides had reduced by 20% and C-reactive protein diminished by 50%. There was also one very important component under the spotlight. The researchers report with statistical certainty that there were no psychological side effects to taking acomplia — a factor that caused the Food and Drug Administration to treat acomplia with suspicion and will be one of the key considerations when Sanofi-Aventis resubmit acomplia to the FDA later this year.

So, on balance, the results of the Stradivarius study are encouraging. They show a continuing pattern of weight loss maintained over time and a reduction in waist measurements among the participants. The study also does not rule out a future role for acomplia in the treatment of heart disease.
HMP

Book review

Well, yes, I am going to talk about a new book. Appropriately enough for a site devoted to Ambien, it is Insomniac by Gayle Greene (published by the University of California Press in March, 2008 — 978-0-520-24630-0). So here is an autobiographical take on what it is like to live with insomnia by a woman who ought to know. Gayle Greene has the distinction of being a non-professional member of the American Academy of Sleep Medicine (AASM). She wins this prize even though not a medical researcher because she is the “patient representative” on the board of the American Insomnia Association, which operates within the AASM’s umbrella. In her spare time (sic), she labours at the Scripps College, Claremont California as Professor of Literature and Women's Studies. This latest tome (quite heavy at 520 pages) adds to her impressive resume of academic publications.

This is a highly personal account by an articulate and intelligent woman who has been afflicted by insomnia for most of her adult life. In one sense, the only person who can really tell you what it is like in a foreign country is one who has been there. For those of us who have always been able to sleep without difficulty, insomnia is like a foreign country, and the idea of having to use a medication like Ambien as the passport to get into sleep is alien.

Conventional wisdom always says that insomnia is somehow related to anxiety or stress levels, perhaps aggravated by drinking too many cups of real coffee. Greene comes up with a simple and practical explanation of what insomnia is. Insomnia means nothing more than you cannot get the number of hours of sleep you need to feel good about yourself and function efficiently. There is no reason for this. It is nothing more than a failure to sleep. There should be no pejorative implication. To use stress as an excuse is to blame the person for being weak or neurotic when there is no reason to blame yourself or anyone else. Instead of looking for some psychological explanation or a less judgemental physical cause, we should just accept that it happens to about 20% of the population at one time or another during their lives. Such a vast number of people yet so little is spent on researching the condition and its causes. Greene comments that the National Institutes of Health in the United States spent less than $20m in 2005, whereas Sanofi-Aventis spent more than $120m promoting Ambien in the same year. This is neither to praise nor condemn Ambien. It is all a question of priorities. Why bother to spend Government money on researching the cause of a condition when private capital has already invented Ambien as a cure for it?

She debates what we really understand about cause and effect. It is so easy to get the cart before the horse, or should that be the other way round? Perhaps conventional wisdom has also got things back-to-front. Instead of stress and anxiety being the cause of insomnia, perhaps living with insomnia makes you stressed and anxious. Who is to say in these more modern times, that we did not have disturbed sleep patterns in past times living on the land? Folk tales may tell us that we went to sleep when dusk fell and waited for the cock to crow before waking. But was that actually the case? Who can say what the real biological norms were before electricity came along and gave everyone the chance to live through the darkness. As it stands, no researcher can actually explain why we have to sleep nor why some people sleep more than others. It is all guesswork.

All that we can say with any certainty is that those who are deprived of sleep do not do as well as those who sleep through the night. The sleepless so often end up demotivated, their sense of humour worn thin, their judgement warped. Some grow fat. Others find their immune system affected. Sleep seems so indispensable yet no-one can really control it. Greene describes everything she has tried over the years from relaxation therapies to medication like Ambien, but concludes that, like any intimate relationship, how we relate to sleep is always personal.

She is a passionate advocate for greater patient power to persuade disinterested bodies to research insomnia.

For one who has had to depend on Ambien and the other medications for so long, she feels she and all other sufferers deserve better answers than those served up by the pharmaceutical companies.

For one who has never had problems sleeping nor had to take Ambien , Insomniac was a riveting insight into the condition and the problems it causes. Required reading for everyone who reads this article.
HMP

21 May 2008

The great Barry Humphries




Recently I bought a memoir by Barry Humphries of Dame Edna and Sir Les Patterson fame entitled More Please, apparently his very first utterance. I am saving the pleasure of starting to read if until I have some more time on my hands but it looks very promising. Some of the pictures of him as a young man are very telling; all arty-looking with foppish long hair and picturesque hats. Great stuff. He is a genius and all the way from Oz as well..








07 May 2008

Alice

Velvet glove as night's startling fingers,
reaching out over the skies sweet embrace,
that tells us of belonging and hurt,
of mermaid tales and oblong tears,
running down a sheet of ice;
a pane of glass,
that mirror that had us almost..
..looking back at us.

Poetry, my erstwhile mistress

At work, a few weeks ago, a friend and colleague of mine with whom I share a passion for poetry and the written word, introduced me to someone who he said was a poet as well. She was a lovely lady who specializes in performance poetry. This, then, was another colleague in the library who would probably rather be a successful author than a library employee, but there you go.

I chatted with her for a while and it soon became apparent that she had not published many of her poems but would like to if given the opportunity. I thought that if I were still editing my poetry magazine I would certainly have invited her to submit.

It is always fun for me to talk about poetry as it is a subject that is not only dear to my heart but I think that I truly understand people's love for it. It's that most gentle and fragile and brutal of arts; unbeatable, really.

04 May 2008

Dentistry

No one really enjoys having to go to the dentist but it is just one of those things in life that you have to deal with. People who had to wear braces as a child probably did not like that but I am sure that now they are all grown up they value having a nice smile, thanks to that corrective procedure. And some dentists are able to provide excellent and advanced techniques making for a very good experience.

For instance, have a look at this Beverly Hill dental site where you can read all about Mr. Maddahi’s practice and the success he has enjoyed providing his superb dental service. This is dentistry with a difference and well worth looking into if you desire excellence and quality care.

Mel Gibson

Just the other day I saw a clip of Mel Gibson talking about something or other. He now looks like an older bloke, all crinkly and wrinkled. No longer the stunning Antipodean cool-meister, he is a new film, the title just escapes me. I don't like anti-Semitism so his recent brush with the LAPD and some of his comments are still fresh in my mind. Oh well...perhaps I'll watch my old video of 'The Year of Living Dangerously' again.

New horror movie

There is a new horror film about to hit the screens and the title of this harrowing flick is Frontier(s). It looks like a must see by all accounts. Would you believe that this film is unrated and uncut and it will go to the cinemas like that? That, in itself, seems rather controversial as most films are carefully rated, especially horror films such as this one. This intriguing looking film will be in selected theatres from May the 9nth so get in early!

The select theater listings are now available from the website. You can see the listing for the major cities right there. You can also download the movie poster from that same website, which is a nice touch. I think I may want to go and see this movie right away. I do love a great film and one with which a certain measure of controversy is involved just makes it all the more enticing, don’t you agree? I am sure that this horror movie won’t disappoint lovers of the genre and movie goers in general. You can’t beat a great new movie in whatever genre but this one looks like a winner. You can buy the film on DVD from May the 13th. Should be good, eh?

Sponsored by Frontier(s)

Houses

Watched an episode of 'Relocation, Relocation, Relocation' last night. The strangest thing about this programme is the female presentor, Kirsty, who although she seems to know what she's talking about tends to put me off by her insane dress sense. She will appear sporting an endless choice of bizarre dresses and strange, wide skirts, bright red tights and odd shoes that seem to big for her somehow. I tend to tune to see what crazy get-up she'll be wearing this time.

03 May 2008

Fashion

Fashion – A classic David Bowie song and a perennial topic of interest to many people, and not just for ladies. A certain sartorial elegance is something that I myself try to aspire to and something that I recognize and admire when I see it in others. Too many people these days are content with going out in public in casual wear when it is clear that playing sports is the last thing on their minds. It doesn’t take much to dress well and to go and buy nice items of clothing when choosing a new set of clothes.

Someone who I think always presents himself well is the actor Gabriel Byrne. Whenever you see him appear on some talk show or other he is turned out well, dressed stylishly and elegantly in a smart suit and shirt combo. He just manages to look the part. That sort of elegance inspires confidence, so perhaps fashion reaches further than just the surface.

A great line of clothing is also to be had from Dockers, who have a great assortment of stylish clothes available. You will look great in some Dockers gear so do by all means check it out. And while you are at it, why not create your own video commercial and enter it for the current Dockers contest, which is now going on.

75x75

Sponsored by Dockers

Boris for Mayor!

Boris Johnson has won the race for Mayor of London. Read all about it here . Well done, Boris! I love the fact that the anti-semitic 'Red' Ken Livingstone has been defeated. Hopefully, Boris will be a good mayor and I'm sure we'll be able to enjoy a few gaffes and cock-ups along the way. But I'm sure he won't be inviting en endless stream of misogynist homophobic muslim clerics and shower them in the official honours at the discretion of the London Mayoral office; something that Livingstone loved doing. Good show, Boris! Now to work..